Table 2. Reported SFs.

Scoring function	Software implementations	Class	Reference(s)
ChemScore	GOLD, FRED, CScore, PRO_LEADS	Empirical	(Eldridge et al., 1997)
eHiTS SF	eHiTS	Empirical	(Zsoldos et al., 2003)
FlexX SF	FlexX	Empirical	(Rarey et al., 1996)
Fresno	Standalone	Empirical	(Rognan et al., 1999)
GlideScore	Glide	Empirical	(Friesner et al., 2004, 2006)
Hammerhead SF	Hammerhead, Surflex, LigandFit	Empirical	(Jain, 1996)
HINT	Standalone	Empirical	(Cozzini et al., 2002)
LigScore	LigandFit	Empirical	(Krammer et al., 2005)
PLP	LigandFit, FRED, DockIt	Empirical	(Gehlhaar et al., 1995)
RankScore	FITTED	Empirical/FF	(Moitessier et al., 2006a)
SAFE_p	None	Empirical/FF	(Sussman et al., 2002)
SCORE	Standalone	Empirical	(Wang et al., 1998)
SCORE 3.0	PSI-DOCK	Empirical	(Pei et al., 2006)
SCORE1	LUDI	Empirical	(Böhm, 1994)
SCORE2	LUDI	Empirical	(Böhm, 1998)
ScreenScore	FRED	Empirical/consensus	(Stahl and Rarey, 2001)
SIE	Standalone	Empirical/FF	(Naim et al., 2007)
SLIDE SCORE	SLIDE	Empirical	(Schnecke and Kuhn, 2000)
VALIDATE	Standalone	Empirical/FF	(Head et al., 1996)
X-Score	Standalone	Empirical/consensus	(Wang et al., 2002)
AutoDock SF	AutoDock, SODOCK	FF/empirical	(Morris et al., 1998)
DockScore	DOCK, CScore	FF	(Meng et al., 1992)
GoldScore	GOLD, CScore	FF	(Jones et al., 1997)
HADDOCK Score	HADDOCK	FF	(van Dijk et al., 2006b)
ICM SF	ICM	FF	(Abagyan et al., 1994b)
QXP SF	QXP/MCDOCK	FF	(McMartin and Bohacek, 1997)
BLEEP	Standalone	Knowledge based	(Mitchell et al., 1999)
DrugScoreCSD	Standalone	Knowledge based	(Velec et al., 2005)
DrugScorePDB	Standalone	Knowledge based	(Gohlke et al., 2000)
M-Score	Standalone	Knowledge based	(Yang et al., 2006)
PMF	CScore, LigandFit, BioMedCAChe, DockIt	Knowledge based	(Muegge and Martin, 1999; Muegge, 2006)
SMoG	SMoG	Knowledge based	(DeWitte and Shakhnovich, 1996; Ishchenko and Shakhnovich, 2002)

Abbreviations: FF, force field; SF, scoring function.