Skip to main content
. 2007 Nov 26;153(Suppl 1):S76–S81. doi: 10.1038/sj.bjp.0707529

Figure 1.

Figure 1

The hamster insulinoma cell line HIT-T15 as a model of insulin-secreting pancreatic β-cells (data kindly provided by Dr J White, (OSI) Prosidion). (a) Expression of GPR119 mRNA in pancreatic tissue and HIT-T15 cells, detected by reverse transcription-PCR using primers representing sequences showing 100% identity between human, rat and mouse GPR119 genes, is shown. (b) Intracellular cyclic AMP levels in HIT-T15 cells treated for 30 min with the GPR119 agonist PSN632408 are shown (Overton et al., 2006). cAMP was determined using the Perkin Elmer AlphaScreen cAMP kit.