Fig. 4.

Kaplan–Meier survival analyses for KO mice. (A) Body weight of male mice in grams. KO mice were separated into two groups, AL and CR. The food was gradually restricted to 40% less than that of the AL-fed KO mice. (B) Kaplan–Meier survival analyses of AL and CR-fed KO mice were performed. n = 30 and n = 32 for AL and CR-fed mice, respectively. The survival curves for the AL and CR-fed KO mice differ significantly by the logrank test; (χ ² = 28.9, P < 0.0001). Green, AL KO; blue, CR KO.