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Comparison of 3D reconstructions of MyBP-C knockout and wild-type thick filaments. (A) Wild type. (B) Knockout. The reconstructions are based on a similar number of segments in each case. Both have been filtered to 7-nm resolution (the resolution of the knockout filaments) to enable a direct comparison. Circle shows altered structure of myosin heads in crown 1 of knockout. (Scale bar, 43 nm.)
