Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Nuclear PTEN represses HIF-1 transcriptional activity. Pten−/− cells were cotransfected with the HRE-Luciferase reporter gene construct and either pLNCX vector control, pLNCX-PTEN (WT), pLNCX-NLS-PTEN, or pLNCX-PTEN (G129R). At 24 h after transfection, cells were exposed to 21% O2 or 1.5% O2 for 16 h. Relative luciferase expression is the ratio of luciferase/total protein levels normalized to pLNCX vector control.
