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The H1047R mutation rescues the cell-transformation phenotypes of the p110α mutants K227E/E542K and K227E/E545K from RAS-binding mutation. (A and B) Focus growth curves for CEFs transfected with RCAS vectors encoding the p110α mutants. EOT, number of foci per nanogram of DNA. The means for two experiments are shown. (C) Western blots comparing the protein expression levels of p110α and the phosphorylation levels of AKT. The assays were carried out as described in Materials and Methods.
