Fig. 1.

LRRK2 induced retinal degeneration. (A) Expression of Flag-LRRK2 and Flag-LRRK2-G2019S in photoreceptor cells. Fly head extracts prepared from the indicated transgenic flies were fractionated and subjected to Western blot analysis using anti-Flag antibodies. (B) Time course of photoreceptor degeneration determined by the optical neutralization technique. Each data point was based on examination of ≥90 ommatidia from at least six flies. Statistically significant differences between control and LRRK2 or LRRK2-G2019S transgenic flies are indicated: *, P < 0.05 by ANOVA. (C) Ommatidia of 5-week-old flies examined by transmission electron microscopy.