Fig. 1.

Structure of Tzs-AMP. (A) Ribbon model. The N- and C-terminal domains and the p loop are light blue, pink, and dark blue, respectively. Carbon, oxygen, phosphorous, and nitrogen atoms of the AMP molecule are green, red, orange, and blue, respectively. In our structure, residues from 228 to the C terminus are disordered. (B) Topology model. The α-helices and β-strands are shown as rectangles and arrows, respectively. A gray background indicates the region that is structurally related to the p loop-containing nucleoside triphosphate hydrolase superfamily (see text for details). (C) Surface model of Tzs. Molecular surface of the AMP-binding side of the reaction channel (Left) and the opposite site (Right), which is rotated by 180° around the vertical axis.