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Determination of APAP-induced liver and kidney injury in wild-type and Cyp2e1-null mice. Serum samples were harvested from wild-type and Cyp2e1-null mice 24 h after the i.p. injection of 200 mg/kg and 400 mg/kg APAP. Values were represented as mean ± SD (n=4, * for P < 0.05 and ** for P < 0.01). A. Alanine aminotransferase (ALT) activity (U/ml). B. Aspartate aminotransferase (AST) activity (U/ml). C. Blood urea nitrogen (BUN) level (mg/dL).
