TABLE 1.
Cumulative outcome of IFN-γ responsesa
| Sample sourceb | IFN-γ response (pg/ml) tod:
|
Peak IFN-γ response (pg/ml) to any one peptide | |||
|---|---|---|---|---|---|
| ML1989 p11 | ML1990 p7 | ML2283 p5 | ML2567 p3 | ||
| PB1 | 0 | 0 | 813 | 52 | 813 |
| PB2 | 0 | 0 | 0 | 946 | 946 |
| PB3 | 231 | 60 | 230 | 0 | 231 |
| PB4 | 0 | 0 | 0 | 205 | 205 |
| PB5 | 222 | 63 | 219 | 292 | 292 |
| PB6 | 102 | 161 | 20 | 0 | 161 |
| Total PB | 3/6 | 1/6 | 3/6 | 3/6 | 6/6c |
| Rx1 | 247 | 0 | 161 | 24 | 247 |
| Rx2 | 0 | 30 | 113 | 0 | 113 |
| Rx3 | 115 | 40 | 143 | 0 | 143 |
| Rx4 | 0 | 0 | 0 | 0 | 0 |
| Total Rx | 2/4 | 0/4 | 3/4 | 0/4 | 3/4c |
| MB1 | 0 | 0 | 0 | 0 | 0 |
| MB2 | 222 | 384 | 220 | 0 | 384 |
| MB3 | 0 | 0 | 0 | 0 | 0 |
| MB4 | 6 | 0 | 1 | 0 | 6 |
| Total MB | 1/4 | 1/4 | 1/4 | 0/4 | 1/4c |
| HHC1 | 529 | 246 | 1,747 | 8 | 1,747 |
| HHC2 | 0 | 201 | 1,284 | 0 | 1,284 |
| HHC3 | 44 | 250 | 2,345 | 20 | 2,345 |
| HHC4 | 0 | 404 | 842 | 0 | 842 |
| HHC5 | 0 | 636 | 694 | 54 | 694 |
| HHC6 | 5 | 462 | 701 | 0 | 701 |
| HHC7 | 0 | 21 | 526 | 51 | 526 |
| HHC8 | 6 | 765 | 0 | 0 | 765 |
| HHC9 | 0 | 317 | 789 | 0 | 789 |
| HHC10 | 0 | 0 | 770 | 0 | 770 |
| HHC11 | 0 | 912 | 1,031 | 0 | 1,031 |
| HHC12 | 40 | 642 | 646 | 0 | 646 |
| HHC13 | 0 | 30 | 0 | 87 | 87 |
| HHC14 | 0 | 500 | 1,183 | 0 | 1,183 |
| Total HHC | 1/14 | 11/14 | 12/14 | 0/14 | 13/14c |
| EC M. leprae+1 | 8 | 15 | 12 | 326 | 326 |
| EC M. leprae+2 | 0 | 0 | 27 | 22 | 27 |
| EC M. leprae+3 | 25 | 287 | 746 | 3 | 746 |
| EC M. leprae+4 | 68 | 34 | 2,885 | 935 | 2,885 |
| EC M. leprae+5 | 280 | 205 | 1,410 | 1,360 | 1,410 |
| EC M. leprae+6 | 77 | 183 | 152 | 137 | 183 |
| EC M. leprae+7 | 29 | 269 | 454 | 0 | 454 |
| Total EC M. leprae+ | 1/7 | 4/7 | 5/7 | 4/7 | 6/7c |
| EC M. leprae−1 | 0 | 0 | 90 | 82 | 90 |
| EC M. leprae−2 | 133 | 183 | 33 | 165 | 165 |
| EC M. leprae−3 | 0 | 0 | 0 | 0 | 0 |
| EC M. leprae−4 | 0 | 0 | 22 | 0 | 0 |
| EC M. leprae−5 | 7 | 0 | 4 | 1 | 7 |
| Total EC M. leprae− | 1/5 | 1/5 | 0/5 | 1/5 | 2/5c |
| NEC1 | 2 | 39 | 0 | 1 | 39 |
| NEC2 | 0 | 1 | 2 | 0 | 2 |
| NEC3 | 0 | 0 | 0 | 0 | 0 |
| NEC4 | 0 | 0 | 0 | 0 | 0 |
| NEC5 | 0 | 12 | 0 | 0 | 12 |
| NEC6 | 0 | 0 | 1 | 0 | 1 |
| NEC7 | 0 | 0 | 0 | 0 | 0 |
| NEC8 | 0 | 0 | 0 | 98 | 98 |
| NEC9 | 0 | 0 | 4 | 38 | 38 |
| NEC10 | 0 | 0 | 0 | 0 | 0 |
| Total NEC | 0/10 | 0/10 | 0/10 | 0/10 | 0/10c |
| TB1 | 3 | 34 | 2 | 0 | 34 |
| TB2 | 0 | 2 | 1 | 0 | 2 |
| TB3 | 62 | 0 | 0 | 0 | 62 |
| TB4 | 0 | 0 | 0 | 0 | 0 |
| TB5 | 15 | 99 | 0 | 0 | 99 |
| TB6 | 0 | 0 | 0 | 0 | 0 |
| TB7 | 5 | 10 | 7 | 17 | 17 |
| TB8 | 5 | 4 | 0 | 0 | 5 |
| TB9 | 0 | 0 | 0 | 0 | 0 |
| TB10 | 0 | 0 | 0 | 0 | 0 |
| Total TB | 0/10 | 1/10 | 0/10 | 0/10 | 0/10c |
| BCG1 | 0 | 0 | 0 | 7 | 7 |
| BCG2 | 0 | 0 | 0 | 0 | 0 |
| BCG3 | 0 | 0 | 0 | 10 | 10 |
| BCG4 | 0 | 0 | 0 | 0 | 0 |
| BCG5 | 0 | 0 | 0 | 22 | 22 |
| BCG6 | 0 | 0 | 0 | 0 | 0 |
| BCG7 | 0 | 0 | 0 | 0 | 0 |
| BCG8 | 0 | 0 | 0 | 0 | 0 |
| BCG9 | 0 | 0 | 0 | 0 | 0 |
| BCG10 | 0 | 0 | 0 | 0 | 0 |
| BCG11 | 0 | 0 | 0 | 0 | 0 |
| Total BCG | 0/11 | 0/11 | 0/11 | 0/11 | 0/11c |
a
All IFN-γ values are corrected for medium values. For each individual, the highest IFN-γ value is depicted as the peak IFN-γ response. Italics show values above the 100-pg/ml cutoff value defining a positive response. EC M. leprae+/−, healthy controls from areas of leprosy endemicity without (−) or with (+) in vitro T-cell responses to M. leprae extracts; NEC, Dutch healthy control individuals.
b
The sample source is identified by test group and donor.
c
The value is the cumulative number of patients with a positive response to any one peptide/total number tested per group.
d
Totals are the numbers of responding donors/total number tested per group.