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. 2008 Jan 30;46(3):1037–1044. doi: 10.1128/JCM.00197-07

TABLE 2.

Characteristics of the 62 IPM-S or IPM-Ins ESBL-producing E. aerogenes isolates

Patient no. Isolate no. Clinical features
Relevant resistance characteristic (IPM-S)c β-Lactamase gene productsd
OMP patterne Gene detected
PFGE type
Source of isolation Ward Patient outcomeb TEM pI value SHV pI value IMP VIM pI value intL3 aac(6′) -Ib
1 1 Stool Polyvalent ICU Improved S TEM-24 6.5 SHV-12 8.2 A
2 Decubitus ulcer R TEM-24 6.5 SHV-12 8.2 IMP-1 >9.5 + + A
2 3 Vaginal exudate Hepatology and gastroenterology Deceased R TEM-24 6.5 SHV-12 8.2 IMP-1 >9.5 + + A
4 Stool S TEM-24 6.5 SHV-12 8.2 − − A
3 5 Blood General and visceral surgery Deceased R TEM-24 6.5 SHV-12 8.2 IMP-1 >9.5 + + A
6 Urine R TEM-24 6.5 SHV-12 8.2 IMP-1 >9.5 + + A
7 Bronchial aspirate R TEM-24 6.5 SHV-12 8.2 IMP-1 >9.5 + + A
8 Anorectal swab R TEM-24 6.5 SHV-12 8.2 IMP-1 >9.5 + + A
4 9 Bronchial aspirate Hepatology and gastroenterology Deceased R TEM-24 6.5 SHV-12 8.2 IMP-1 >9.5 + + A
5 10 Stool Hepatology and gastroenterology Deceased S TEM-24 6.5 SHV-12 8.2 − − A
11 Deep pus R TEM-24 6.5 SHV-12 8.2 IMP-1 >9.5 − + B
12 Deep pus S TEM-24 6.5 SHV-12 8.2 − − A
13 Anorectal swab S TEM-24 6.5 SHV-12 8.2 − − A
6 14 Bronchial aspirate General and visceral surgery Deceased S TEM-24 6.5 SHV-12 8.2 − − A
15 Bone biopsy R TEM-24 6.5 SHV-12 8.2 IMP-1 >9.5 + + A
16 Anorectal swab S SHV-12 8.2 A
17 Anorectal swab R TEM-24 6.5 SHV-12 8.2 IMP-1 >9.5 + + A
7 18 Blood Hepatology and gastroenterology Deceased R TEM-24 6.5 SHV-12 8.2 IMP-1 >9.5 + + A
19 Anorectal swab S TEM-24 6.5 SHV-12 8.2 A
20 Peritoneal fluid R TEM-24 6.5 SHV-12 8.2 IMP-1 >9.5 − + A
21 Anorectal swab R TEM-24 6.5 SHV-12 8.2 IMP-1 >9.5 + + A
22 Stool R TEM-24 6.5 SHV-12 8.2 IMP-1 >9.5 + + A
8 23 Bile General and visceral surgery Deceased S TEM-24 6.5 SHV-12 8.2 − − A
24 Blood R TEM-24 6.5 SHV-12 8.2 IMP-1 >9.5 + + A
9 25 Bronchial aspirate General and visceral surgery Deceased S TEM-24 6.5 SHV-12 8.2 − − A
26 Bronchial aspirate S TEM-24 6.5 SHV-12 8.2 − − A
27 Deep pus R TEM-20 5.4 IMP-1 >9.5 − + A
28 Femoral catheter S TEM-20 5.4 − − A
10 29 Anorectal swab Hepatology and gastroenterology Improved R TEM-24 6.5 SHV-12 8.2 IMP-1 >9.5 + + A
11 30 Bronchial aspirate Polyvalent ICU Deceased S TEM-20 5.4 − − A
31 Bronchial aspirate R TEM-24 6.5 SHV-12 8.2 IMP-1 >9.5 + + A1
12 32 Bronchial aspirate Respiratory ICU Deceased I TEM-24 6.5 SHV-12 8.2 IMP-1 >9.5 + + A
33 Anorectal swab Respiratory ICU S TEM-24 6.5 SHV-12 8.2 A
13 34 Anorectal swab Hepatology and gastroenterology Improved S TEM-20 5.4 A
35 Bile R TEM-20 5.4 IMP-1 >9.5 − + A
14 36 Urine General and visceral surgery Improved I TEM-24 6.5 SHV-12 8.2 IMP-1 >9.5 + + A
37 Urine R TEM-24 6.5 SHV-12 8.2 IMP-1 >9.5 + + A
15 38 Deep pus Polyvalent ICU Improved R TEM-24 6.5 SHV-12 8.2 IMP-1 >9.5 − + C
39 Anorectal swab S TEM-24 6.5 SHV-12 8.2 A
16 40 Anorectal swab Polyvalent ICU Improved S SHV-5 8.2 OmpK42+ OmpK32+ − − A
41 Tracheal aspirate R SHV-5 8.2 OmpK42± OmpK32+ + + A
17 42 Anorectal swab General and visceral surgery Improved R TEM-24 6.5 SHV-12 8.2 OmpK42− OmpK32+ + + A
43 Anorectal swab S TEM-24 6.5 SHV-12 8.2 OmpK42+ OmpK32+ − − A
44 Jugular exudate S TEM-24 6.5 SHV-12 8.2 OmpK42+ OmpK32+ − − A
18 45 Deep pus Polyvalent ICU Deceased R TEM-24 6.5 SHV-5 8.2 VIM-2 5.3 + + A
58 Bronchial aspirate R SHV-5 8.2 VIM-2 5.3 + + A
19 46 Intravascular catheter Polyvalent ICU Improved R TEM-24 6.5 SHV-12 8.2 IMP-1 >9.5 + + A
20 47 Anorectal swab General and visceral surgery Deceased I SHV-12 8.2 OmpK42± OmpK32+ − + F
48 Decubitus ulcer I SHV-12 8.2 OmpK42± OmpK32+ + + A
49 Blood R SHV-12 8.2 OmpK42± OmpK32+ + + E
50 Pancreatic biopsy S SHV-12 8.2 OmpK42+ OmpK32+ − − A
51 Urine S SHV-12 8.2 OmpK42+ OmpK32+ − − E
52 Peritoneal fluid R SHV-12 8.2 OmpK42± OmpK32+ + + E
53 Pancreatic biopsy R SHV-12 8.2 OmpK42± OmpK32+ + + A2
54 Deep pus R SHV-12 8.2 OmpK42± OmpK32+ + + A1
55 Peritoneal fluid R SHV-12 8.2 OmpK42± OmpK32+ + + A2
56 Wound exudate R SHV-12 8.2 OmpK42± OmpK32+ + + A1
57 Blood R SHV-12 8.2 OmpK42± OmpK32+ + + A1
21 59 Anorectal swab Hepatology and gastroenterology Improved S TEM-24 6.5 SHV-12 8.2 OmpK42+ OmpK32+ − − C
60 Anorectal swab R SHV-12 8.2 OmpK42− OmpK32+ − − D
22 61a Tracheal aspirate Polyvalent ICU S OmpK42+ OmpK32+ − − A
62a Blood R OmpK42− OmpK32+ − − A3
HB101 Strain S OmpK45+ OmpK42+ OmpK38+ OmpK32+
a

Isolates 61 and 62 were derepressed cephalosporinase producers.

b

The outcome was favorable with respect to the E. aerogenes infections.

c

S, susceptible; I, intermediate; R, resistant.

d

The ESBL and MBL genes shown in bold type were sequenced. Some additional ESBLs and MBLs, shown in regular type, were identified by phenotypic, biochemical, and PCR tests, but the genes were not sequenced.

e

OmpK+, presence of Omp band; OmpK−, absence of Omp band; OmpK±, presence of weak Omp band.