TABLE 2.
Sensitivities and specificities of Int-PCR diagnostics for detection of antibiotic resistancea
| Antibiotic | 1,000-bp group
|
1,000-bp + 1,200-bp group
|
1,600-bp group
|
Any integron
|
||||
|---|---|---|---|---|---|---|---|---|
| Sensitivity (95% confidence interval) | Specificity (95% confidence interval) | Sensitivity (95% confidence interval) | Specificity (95% confidence interval) | Sensitivity (95% confidence interval) | Specificity (95% confidence interval) | Sensitivity (95% confidence interval) | Specificity (95% confidence interval) | |
| Amox | 0 (0.00-0.84) | 0.61 (0.57-0.64) | 0 (0.00-0.84) | 0.94 (0.92-0.96) | 0 (0.00-0.84) | 0.98 (0.97-0.99) | 0 (0.00-0.84) | 0.54 (0.53-0.61) |
| Amp | 0.02 (0.01-0.12) | 0.58 (0.55-0.62) | 0.89 (0.76-0.96) | 1 (0.99-1.00) | 0 (0.00-0.10) | 0.98 (0.97-0.99) | 0.91 (0.79-0.98) | 0.57 (0.53-0.61) |
| Cef | 0 (0.00-0.71) | 0.61 (0.57-0.64) | 0 (0.00-0.71) | 0.94 (0.92-0.96) | 0 (0.00-0.71) | 0.98 (0.97-0.99) | 0 (0.00-0.71) | 0.54 (0.50-0.57) |
| Cm | 0.02 (0.00-0.07) | 0.55 (0.51-0.59) | 0.41 (0.31-0.51) | 1 (0.99-1.00) | 0 (0.00-0.04) | 0.98 (0.97-0.99) | 0.43 (0.33-0.53) | 0.53 (0.49-0.57) |
| Gen | 0.5 (0.28-0.72) | 0.61 (0.58-0.65) | 0 (0.00-0.15) | 0.94 (0.92-0.96) | 0.5 (0.28-0.72) | 0.99 (0.99-1.00) | 1 (0.85-1.00) | 0.55 (0.51-0.59) |
| Kan | 0 (0.00-0.12) | 0.59 (0.56-0.63) | 0 (0.00-0.12) | 0.94 (0.92-0.96) | 0.27 (0.13-0.47) | 0.99 (0.99-1.00) | 0.28 (0.13-0.47) | 0.53 (0.49-0.57) |
| St | 0.76 (0.71-0.80) | 0.95 (0.93-0.97) | 0.12 (0.08-0.15) | 1 (0.99-1.00) | 0.03 (0.02-0.06) | 1 (0.99-1.00) | 0.91 (0.87-0.94) | 0.95 (0.93-0.97) |
| Su | 0.69 (0.64-0.73) | 1 (0.98-1.00) | 0.1 (0.07-0.13) | 1 (0.99-1.00) | 0.03 (0.01-0.05) | 1 (0.99-1.00) | 0.81 (0.77-0.83) | 1 (0.99-1.00) |
| Tet | 0.61 (0.56-0.66) | 0.95 (0.92-0.97) | 0.09 (0.07-0.12) | 1 (0.99-1.00) | 0.03 (0.01-0.05) | 1 (0.99-1.00) | 0.73 (0.69-0.77) | 0.95 (0.94-0.97) |
| Spc | 0.71 (0.66-0.75) | 1 (0.99-1.00) | 0.1 (0.07-0.14) | 1 (0.99-1.00) | 0.03 (0.02-0.05) | 1 (0.99-1.00) | 0.84 (0.80-0.88) | 1 (0.99-1.00) |
a
Amox, amoxicillin; Amp, ampicillin; Cef, cefoxitin; Cm, chloramphenicol; Gen, gentamicin; Kan, kanamycin; St, streptomycin; Su, sulfisoxazole; Tet, tetracycline; Spc, spectinomycin. Ninety-five-percent exact binomial confidence intervals are reported.