Table 3.
The relationship between the severity of Batten disease (34) and ANP resistance in yeast with corresponding alterations
| Cln3p (human)
|
Btn1p (yeast)
|
||
|---|---|---|---|
| Alteration | Batten disease severity | Alteration | ANP resistance |
| Deletion | +++ | Deletion | +++ |
| L101P | ++ | L44P | ++ |
| L170P | + | L112P | 0 |
| E295K | + | E243K | 0 |
| V330F | +++ | V289F | + |
| R334C | +++ | R293C | ++ |
| R334H | +++ | H293H | ++ |
| None | 0 | None | 0 |
B-10196 (btn1-Δ cyc1-Δ) was transformed with single copy plasmids, and the growth of the resulting strains was determined on YPD containing 2 mg/ml of ANP.