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Model of Nap1 function during transcription. The TREX complex component Yra1 directly recruits Nap1 to a site of active transcription. (A) Nap1 facilitates the reincorporation of H2A/H2B dimers and octamer reassembly on the open template following RNAP II (Pol II) progression. (B) Nap1 may also function in H2A/H2B disassembly preceding RNAP II. (C) Nap1 also mediates histone mobilization at other regions, such as the promoter in Yra1-independent mechanisms.
