TABLE 2.
MPC statusa | CD marker | Result forb:
|
EFT statusc | SK-ES1 | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|
UET-13
|
UET-13TR
|
UET-13TR- EWS/FLI1
|
UET-13TR- EWS/ERG
|
RD-ES | |||||||
Tet− | Tet+ | Tet− | Tet+ | Tet− | Tet+ | ||||||
M+ | CD29 | + | + | + | + | + | + | + | + | + | |
M+ | CD59 | + | + | + | + | + | + | + | + | + | |
M+ | CD90 | + | + | + | + | + | + | + | + | + | E+ |
M+ | CD105 | + | + | + | + | + | + | + | + | + | |
M+ | CD166 | + | + | + | + | + | + | + | + | + | |
M+ | CD44 | + | + | + | + | + | + | + | − | − | |
M+ | CD73 | + | + | + | + | + | + | + | − | − | |
M+ | CD10 | + | + | + | + | Down | + | Down | − | − | |
M+ | CD13 | + | + | + | + | Down | + | Down | − | − | |
M+ | CD49e | + | + | + | + | Down | + | Down | + | − | |
M+ | CD61 | + | + | + | + | Down | + | Down | − | − | |
M+ | CD55 | + | + | + | + | Down | + | + | + | − | |
M+ | CD54 | − | − | − | − | Up | − | Up | + | + | E+ |
M(−) | CD117 | − | − | − | − | Up | − | Up | + | + | E+ |
M+/− | CD271 | − | − | − | − | Up | − | Up | + | + | E+ |
CD40 | − | − | − | − | − | − | − | + | + | E+ | |
CD56 | − | − | − | − | − | − | − | + | + | E+ | |
M(−) | CD133 | − | − | − | − | − | − | − | + | + | |
M(−) | CD14 | − | − | − | − | − | − | − | − | − | |
M(−) | CD34 | − | − | − | − | − | − | − | − | − | |
M(−) | CD45 | − | − | − | − | − | − | − | − | − |
M(−), negative for MPCs; M+/−, positive for BM-derived MPCs but negative after in vitro culture; M+, positive for MPCs.
+, most cells positive; −, negative; Up, up-regulated by tetracycline treatment; Down, down-regulated by tetracycline treatment. Boldface indicates the antigens the immunophenotypes of which were changed in favor of EFT. Tet−, tetracycline negative; Tet+, tetracycline positive.
E+, positive for EFTs.