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Histopathology (with H&E) of BASE strain-infected and sCJDMM1-infected Tg(HuPrP) mice. (A) No consistent pathology was detected in the cerebral cortex as well as subcortical brain regions of symptomatic and immunoblot-positive BASE strain-infected Tg(HuPrP) (Tg40) mice. (B) In contrast, Tg40 mice inoculated with sCJDMM1 brain homogenate showed widespread spongiform degeneration.
