TABLE 4.
ORs for HCC with different number of mutations in different HBV genotypes/subtypes
| Genotype and no. of mutations | Case-control study
|
Validation cohort
|
||||||
|---|---|---|---|---|---|---|---|---|
| No. in group
|
OR (95% CI) | P | No. in group
|
OR (95% CI) | P | |||
| HCC | Non-HCC | HCC | Non-HCC | |||||
| B | ||||||||
| 0 | 3 | 16 | Referent | 1 | 23 | Referent | ||
| 1 | 0 | 6 | 0.36 (0.02-8.04)a | 0.55 | 1 | 2 | 11.50 (0.50-261.97) | 1.00 |
| 2 | 7 | 13 | 2.87 (0.62-13.37) | 0.27 | 7 | 5 | 32.20 (3.20-323.67) | 0.0006 |
| 3 | 21 | 12 | 9.33 (2.25-38.71) | 0.001 | 7 | 10 | 16.10 (1.74-148.68) | <0.0001 |
| 4 | 6 | 4 | 8.00 (1.37-46.81) | 0.03 | 1 | 1 | 13.65 (2.31-84.43) | 0.0009 |
| 5 | 0 | 0 | Undefined | 1 | 0 | 47.00 (1.28-1722.22)a | 0.11 | |
| Ce | ||||||||
| 0 | 3 | 7 | Referent | 0 | 7 | Referent | ||
| 1 | 6 | 3 | 4.67 (0.67-32.36) | 0.18 | 4 | 0 | 135.00 (2.26-8069.03)a | 0.001 |
| 2 | 5 | 0 | 23.57 (1.00-556.11)a | 0.03 | 3 | 1 | 35.00 (1.12-1094.80)a | 0.0008 |
| 3 | 2 | 0 | 10.71 (0.40-287.84) | 0.15 | 1 | 0 | 45.00 (0.61-3297.13)a | 0.02 |
| Cs | ||||||||
| 0 | 12 | 29 | Referent | 2 | 27 | Referent | ||
| 1 | 18 | 9 | 4.83 (1.70-13.75) | 0.002 | 7 | 9 | 10.50 (1.84-60.01) | <0.0001 |
| 2 | 12 | 1 | 29.00 (3.38-248.49) | <0.0001 | 3 | 4 | 10.13 (1.27-80.61) | <0.0001 |
| 3 | 5 | 0 | 25.96 (1.33-505.87)a | 0.005 | 4 | 0 | 99.00 (4.05-2418.57)a | <0.0001 |
| 4 | 0 | 0 | Undefined | 0 | 0 | Undefined | ||
a
Haldane's approximation was used for estimation of the OR and 95% CI.