TABLE 5.
Amino acid mutations in different genotypes associated with HCC development
| Genotype | Nucleotide
|
Amino acid in region:
|
|||||
|---|---|---|---|---|---|---|---|
| Position | Wild type | Mutant | Surface | Polymerase | Precore/core | X | |
| B | 1165 | C | T | RNase H, P2S | |||
| 1762 | A | T | K130M | ||||
| 1764 | G | A | V131I | ||||
| 2525 | A, T | C | TP, K/N73N | ||||
| 2712 | T | C/A/G | TP, Y136H/N/D | ||||
| Ce | 31 | T | C | Pre-S1, D134 (no change) | Spacer, S137P | ||
| 53 | T | C | Pre-S1, F141L | Spacer, L144P | |||
| 1499 | A | G | RNase H, H113R | P43 (no change) | |||
| Cs | 1613 | G | A | RNase H, R151K | E80 (no change) | ||
| 1899 | G | A | Precore, G29D | ||||
| 2170 | T | C/G | Core, N90N/K | ||||
| 2441 | T | C | N45 (no change) | Core, S181P | |||