FIG. 5.

Alignment of the CCMV and HCMV US6 protein sequences. The HCMV and CCMV US6 protein sequences were aligned using the Vector NTI Suite software (Invitrogen), and identical residues are highlighted in gray. The transmembrane domains and signal sequences were predicted with PSORT II (32); the predicted signal sequences for both proteins are shown in italic type. The cleavage site is indicated by an arrow. Residue 1 corresponds to the N-terminal residue of the protein after signal peptide cleavage. The predicted transmembrane domains are underlined. Consensus sites for N-linked glycosylation sites are shown in bold type, and residues 89 to 108 in HCMV US6 and the corresponding region in CCMV US6 are boxed.