FIG. 5.

Functional Jak/STAT and NF-κB pathways are not needed for apoptosis. A. U4C cells, which lack JAK1 and the interferon response, were pretreated with the PI3 kinase inhibitor LY294002 for 30 min. Cells were then mock infected (control) or infected with Sendai virus in the absence or presence of LY as indicated. Six hours after virus addition, cells were fixed, permeabilized, and stained. B. 2f-SR cells, which constitutively express the IκB superrepressor and subsequently fail to activate NF-κB, were treated as for panel A.