FIG. 9.

SeV-induced apoptotic pathway. Infection of cells with SeV activates IRF-3, which in turn induces expression of virus stress-inducible genes and causes host cell apoptosis. In addition, virus infection also activates the PI3 kinase pathway, which is needed for replication of virus and generation of antiapoptotic signal in the host cells. Blocking the PI3 kinase pathway by chemical inhibitors induces early apoptosis of the host cells. A suitable balance between the apoptotic and antiapoptotic signals dictates the fate of the infected cell; however, the apoptotic signal is determined by the activation of IRF-3.