. 2008 Jan 18;7(3):454–464. doi: 10.1128/EC.00408-07

TABLE 1.

Genes downregulated by zinc limitation

Gene	Function^a	Relative mRNA level (level in zrt1-II1 cells/level in wild-type cells)
Gene	Function^a	Expt 1	Expt 2	Mean
isp3⁺	Upregulation of meiotic expression	0.196	0.047	0.12
pho1⁺	Acid phosphatase	0.113	0.176	0.14
SPAC27D7.10c	Similar to SPAC27D7.09c, SPAC27D7.11c, and SPBC3D6.02	0.249	0.178	0.21
str3⁺	Siderophore-iron transporter	0.218	0.210	0.21
SPBPB10D8.02c	Acylsulfatase (predicted)	0.310	0.144	0.23
SPBC359.03c	Amino acid permease family (predicted)	0.274	0.201	0.24
SPCC965.14c	Cytosine deaminase (predicted) zinc metalloenzyme	0.258	0.240	0.25
SPAC27D7.09c	Similar to SPAC27D7.10c, SPAC27D7.11c, and SPBC3D6.02	0.332	0.169	0.25
wis2⁺	Cyclophilin	0.311	0.269	0.29
SPAC11D3.18c	Nicotinic acid plasma membrane transporter (predicted)	0.262	0.334	0.30
SPAC27D7.11c	Similar to SPAC27D7.09c, SPAC27D7.10c, and SPBC3D6.02	0.405	0.199	0.30
SPAC869.05c	Sulfate transporter (predicted)	0.367	0.248	0.31
SPBC1347.11	Sequence orphan	0.442	0.207	0.32
SPBC1539.07c	Glutathione-dependent formaldehyde dehydrogenase (predicted)	0.371	0.302	0.34
SPBC3E7.06c	Major facilitator superfamily membrane transporter	0.335	0.355	0.35
pan6⁺	Pantoate-beta-alanine ligase	0.360	0.336	0.35
SPAC11D3.02c	ELLA family protein	0.368	0.342	0.36
SPBC21C3.08c	Ornithine aminotransferase	0.432	0.294	0.36
SPBPB10D8.01	Membrane transporter	0.405	0.371	0.39
aes1⁺	Enhancer of RNA-mediated gene silencing	0.460	0.348	0.40
SPCC364.07	D-3 phosphoglycerate dehydrogenase (predicted)	0.464	0.368	0.42
SPBP8B7.05c	Carbonic anhydrase (predicted)	0.501	0.343	0.42
apt1⁺	Adenine phosphoribosyltransferase (predicted)	0.423	0.422	0.42
SPAC23C4.06c	Methyltransferase (predicted)	0.409	0.450	0.43
SPBC8E4.01c	Inorganic phosphate transporter (predicted)	0.513	0.366	0.44
SPAC11D3.13	ThiJ domain	0.454	0.451	0.45
rpl3002⁺	60S ribosomal protein L30	0.516	0.391	0.45
rpl31⁺	60S ribosomal protein L31	0.508	0.399	0.45
SPBC359.01	Amino acid permease family	0.538	0.375	0.46
SPCC330.06c	Thioredoxin peroxidase	0.566	0.349	0.46
eca39⁺	Branched-chain amino acid aminotransferase	0.486	0.429	0.46
SPCC622.12c	NADP-specific glutamate dehydrogenase	0.462	0.454	0.46
egd2	Nascent polypeptide-associated complex (alpha subunit)	0.549	0.374	0.46
sks2⁺	Heat shock protein 70 family	0.539	0.387	0.46
SPBPB2B2.05	GMP synthase	0.532	0.399	0.47
rpb8⁺	DNA-directed RNA polymerase I, II, and III subunit	0.561	0.371	0.47
SPCP20C8.03	Pseudogene	0.491	0.448	0.47
SPAP8A3.07c	Phospho-2-dehydro-3-deoxyheptonate aldolase	0.588	0.360	0.47
SPBC428.11	Homocysteine synthase	0.562	0.389	0.48
SPBC13A2.04c	PTR family peptide transporter	0.518	0.434	0.48
rpl34⁺	60S ribosomal protein L34	0.591	0.368	0.48
SPBPB2B2.06c	Calcineurin-like phosphoesterase	0.579	0.385	0.48
SPCC330.07c	Membrane transporter	0.437	0.530	0.48
cdb4⁺	Metallopeptidase	0.537	0.431	0.48
meu19⁺	Noncoding RNA	0.566	0.403	0.48
hsp90⁺	Hsp90 family	0.555	0.420	0.49
rps403⁺	40S ribosomal protein S4	0.598	0.383	0.49
sod1⁺	Superoxide dismutase	0.525	0.462	0.49
snz1⁺	pyridoxine biosynthesis protein	0.479	0.513	0.50
rpl1101⁺	60S ribosomal protein L11	0.533	0.461	0.50
ssa1⁺	Heat shock protein 70 family	0.563	0.433	0.50
rps801⁺	40S ribosomal protein S8	0.544	0.452	0.50
ubc15⁺	Ubiquitin-conjugating enzyme	0.502	0.497	0.50
isu1⁺	Iron-sulfur cluster assembly scaffold protein	0.638	0.362	0.50
SPCC1442.14c	Adenosine 5′-monophosphoramidase	0.559	0.446	0.50
sua1⁺	Sulfate adenylyltransferase (ATP)	0.610	0.396	0.50
ura1⁺	Carbamoyl-phosphate synthase	0.525	0.482	0.50

The descriptions of the protein functions are based on information for S. pombe in GeneDB (http://www.genedb.org/genedb/pombe/index.jsp).