Table 2.
Broad-spectrum activity of 1 against BSL2 CLSI quality control strains, compared to MICs of pexiganan as determined by Ge et al. (44)
| Microorganism | Clinical relevance | Peptoid 1 MIC, μM | Pexiganan MIC, μM |
|---|---|---|---|
| Streptococcus pneumoniae ATCC 49619 | Leading cause of community-acquired pneumonia | 1.7–3.4 | 13 |
| Haemophilus influenzae ATCC 49247 | Second-most common cause of community-acquired pneumonia | 6.9 | 3.2 |
| Staphylococcus aureus ATCC 33591 | Leading cause of antibiotic-resistant nosocomial infection. This strain is methicillin resistant. | 3.4 | 6.5–13 |
| Escherichia coli ATCC 25922 | Common Gram-negative pathogen | 14–28 | 3.2–6.5 |
| Enterococcus faecalis ATCC 29212 | E. faecalis has evolved resistance to the toughest of antibiotics (e.g. vancomycin) | 3.4–6.9 | 26 |
| Pseudomonas aeruginosa ATCC 27853 | Highly unresponsive to many antibiotic treatments | 28 | 3.2–6.5 |