Fig. 1.

Phylogenetic tree of mouse LPLAT family and summary of characterized LPLATs. (A) A phylogenetic tree was drawn by using ClustalW (www.ebi.ac.uk/clustalw). Values show branch lengths that represent the evolutional distance between each pair of sequences. Putative LPLAT genes are indicated by asterisks. Sequence data of mouse acyltransferases are available in the DDBJ/European Molecular Biology Laboratory/GenBank databases. The accession numbers are shown in SI Table 4. (B) Functionally identified LPLATs were summarized. Darker colors indicate higher enzymatic activity for acyl-CoAs. The enzymes LPCAT3, LPCAT4, and LPEAT1 are marked as being shown in this study. Additional LPLATs that may exist are indicated with question marks. GPAT, glycerol-3-phosphate acyltransferase; MGAT, monoacylglycerol O-acyltransferase; ACAT, sterol O-acyltransferase; LRC4, leukocyte receptor cluster member 4.