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. 2008 Feb 19;105(8):2889–2894. doi: 10.1073/pnas.0800178105

Fig. 5.

Fig. 5.

siRNA-mediated knockdown of Rb2/p130 accelerates adipocyte differentiation. (A) siRNA knockdown of Rb2/p130 accelerated adipocyte differentiation (Right) compared with control siRNA (Left), as shown by oil red O staining and measured by the area of red and integrated density 7 days after hormonal induction. (B) QRT-PCR analyses of key adipocyte markers during 3T3L1 adipocyte differentiation. The y axis represents the mRNA expression ratio of Ap2, Lpl, and Srebp between the cells transfected with siRNA against Rb2/p130 and the cell transfected with control siRNA at 48 h after induction. The siRNA transfection was performed 6 h before hormonal induction. The data shown are mean ratios and SDs of three replicates.