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The ratio of tumor-infiltrating CD8+ T cells to FoxP3+ Tregs after Ipilumimab infusion is tightly correlated with the extent of tumor necrosis. (A Upper) Minimal necrosis of melanoma metastasis. (Lower) Extensive necrosis of melanoma metastasis. (Magnification: H&E, ×4; CD8, ×20; FoxP3, ×40.) (B) Numbers of intratumoral FoxP3+ Tregs and CD8+ T cells versus tumor necrosis.
