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. 2008 Feb 14;105(8):3011–3016. doi: 10.1073/pnas.0712278105

Fig. 3.

Fig. 3.

The IgV domains of PD1/PD-L1 are similar to antigen receptors. (A) The loops at the ends of the PD-1 domain and the first domain of PD-L1 are located on the same side of the complex. (B) For comparison, the Fv or VHVL portion of a representative antibody [PDB ID code 1G7J (31)] found in the search of the database was superimposed on the Fv-like portion of the PD-1/PD-L1 complex to yield an rms difference of 2.6 Å over 180 pairs of α-carbon pairs. (C) The VαVβ portion of a representative TCR [PDB ID code 2BNU (32)] was superimposed on the Fv-like part of the PD-1/PD-L1 complex with an rms difference of 3.1 Å over 191 Cα pairs. In B and C, after superimposing on to PD-1/PD-L1, the models were translated apart for viewing. The loops that are antigen receptor CDRs are labeled (CDR1, CDR2, and CDR3). The search of the database was performed with the PD-1/PD-L1 Fv-like domain as query and all of the targets considered as two-domain rigid bodies.