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. 2008 Feb 14;105(8):3059–3063. doi: 10.1073/pnas.0712265105

Fig. 5.

Fig. 5.

Diminished hypertrophic response of PKD1 cKO mice to ISO infusion. (A) Hearts of WT and PKD1 cKO mice chronically infused with either saline vehicle (WT and PKD1 cKO; n = 6) or isoproterenol (8.7 mg/kg per day) for 7 days (Top; n = 11; PKD1 cKO, n = 16), histological sections stained with H&E (Middle) or Masson's trichrome to detect fibrosis (Bottom). (Scale bars: Top and Middle, 2 mm; Bottom, 40 μm.) (B) Heart weight/tibia length (HW/TL) ratios (±SEM) are shown as bar graphs (n = 7–9). (C) Transcripts for markers of hypertrophy in hearts from WT and PKD cKO mice infused with either saline vehicle or isoproterenol. Values indicate relative expression level to a WT sham-operated group (±SEM). ANF, atrial natriuretic factor; β-MHC, β-myosin heavy chain; Col1α2, procollagen, type I, α2.