Table 1.
SEREX-defined genes identified by allogeneic screening of SK-MEL-37 cDNA expression library
| Gene group | No. of clones | Comments |
|---|---|---|
| KOC | 33 | Derived from three related genes, overexpressed antigen |
| MAGE | 11 | Predominantly MAGE-4a (see text) |
| NY-ESO-1 | 5 | Derived from two related genes (NY-ESO-1, LAGE-1) |
| CT7 | 2 | New cancer/testis antigen (see text) |
| Miscellaneous | 2 | S-adenyl homocysteine hydrolase |
| 1 | Glutathione synthetase | |
| 1 | Proliferation-associated protein p38-2G4 | |
| 1 | Phosphoribosyl pyrophosphate synthetase-associated protein 39 | |
| 1 | Unknown gene, identical to ESTs from pancreas, uterus, etc. | |
| 1 | Unknown gene, identical to ESTs from lung, brain, fibroblast, etc. | |
| 1 | Unknown gene, identical to ESTs from multiple tissues | |
| 1 | Unknown gene, identical to ESTs from pancreas and fetus | |
| 1 | Unknown gene, no identical EST sequence, universally expressed |
EST, expressed sequence tags.