Skip to main content
. Author manuscript; available in PMC: 2008 Mar 17.
Published in final edited form as: Breast Cancer Res Treat. 2007 May 17;108(1):43–55. doi: 10.1007/s10549-007-9587-7

Fig. 1.

Fig. 1

Strategy to exploit translational targeting as an adjunct to transcriptional targeting. (A) Construction of pAdenoVator-CXCR4. This construct contains the 279 bp CXCR4 promoter and the simian virus 40 (SV40) polyadenylation (poly A) signal. (B) The adenoviral type 5 E1AcDNA was cloned by PCR into pAdenoVator-CXCR4 to generate the pAdenoVator-CXCR4-E1A plasmid. (C) The 5′ upstream-untranslated region sequence of the rat FGF-2 cDNA was inserted immediately upstream of the E1A sequence to produce the pAdenoVator-CXCR4-UTR-E1A plasmid.