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. Author manuscript; available in PMC: 2008 Mar 17.
Published in final edited form as: Breast Cancer Res Treat. 2007 May 17;108(1):43–55. doi: 10.1007/s10549-007-9587-7

Fig. 6.

Fig. 6

Dual-level targeting exploiting both gene transcriptional and mRNA translational control displays cytotoxic specificity in cells over expressing eIF4E. Oncolysis was evaluated by crystal violet staining in normal cells expressing relatively low levels of eIF4E (A) and breast cancer cell lines expressing relatively high levels of eIF4E (B) after infection with Ad-CXCR4-E1A, Ad-CXCR4-UTR-E1A, Ad-CXCR4-GL3 (negative control) or Ad-wt-dE3 (positive control) as described in Material and methods.