Table 2.
5-HT1A binding density, binding distribution area and binding capacity changes in the dorsal raphe nucleus (DRN) depending on group membership (depressed suicides versus controls) and DRN rostrocaudal level
| Measure | Factors | df | F | p |
|---|---|---|---|---|
| 5-HT1A binding (fmol/mg tissue) | Group | 1,18 | 2.20 | .1555 |
| Level | 5,14 | 11.08 | .0002 | |
| Group * Level | 5,14 | 11.61 | .0001 | |
| 5-HT1A binding distribution area (mm2) | Group | 1,18 | 14.76 | .0012 |
| Level | 5,15 | 14.85 | <.0001 | |
| Group * Level | 5,14 | 4.19 | .0154 | |
| 5-HT1A binding capacity (fmol/mg tissue* mm3) | Level | 5,14 | 26.62 | <.0001 |
| Group | 1,18 | 18.06 | .0005 | |
| Group * Level | 5,14 | 5.05 | .0075 |
Group = depressed suicides vs. controls; Level = DRN rostrocaudal level of tissue sections; Group * Level = group by rostrocaudal level interaction.