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. 2008 Feb 26;9:27. doi: 10.1186/1471-2202-9-27

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Copyright © 2008 Grigorian et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Nelfinavir increases NICD nuclear localization. CEC exposed to saquinavir (SQV), indinavir (INV), nelfinavir (NFV), and ritonavir (RTV) for 48 h were assessed for nuclear localization of NICD (green) and double labeled with actin (red). The percentage of cells positive for NICD nuclear localization was calculated by counting at least 10 random fields of view and at least 200 cells per condition. 60× magnification. *p ≤ 0.001 by one way ANOVA with Dunnett's post hoc tests when compared to control. **p ≤ 0.001 by one way ANOVA with Tukey-Kramer post hoc tests when compared to NFV treated cells.