Table 3.
Antibody specific for bovine CII (bCII) and murine CII (mCII) at days 35 and 55 after bovine CII immunization
| Strain | Mean IgG (μg/ml)† | ||
|---|---|---|---|
| bCII day 55 | mCII
|
||
| day 35 | day 55 | ||
| DBA/1 | 698 (430–966) | 111 (46–176) | 620 (87–1153) |
| DR4/huCD4 tg | 1023 (415–1631) | 68 (8–120) | 1188 (308–2068) |
| Non tg | 0 | ND | ND |
| Strain | Mean IgG1 (μg/ml) mCII
|
Mean IgG2a (μg/ml) mCII
|
||
|---|---|---|---|---|
| day 35 | day 55 | day 35 | day 55 | |
| DBA/1 | 26 (1–51) | 101 (6–196) | 22 (9–35) | 128 (15–241) |
| DR4/huCD4 tg | 30 (2–56) | 233 (74–392) | 29 (2–56) | 496 (158–834) |
| Non tg | ND | ND | ND | ND |
†
Only results from experimental group 1 are shown but are analogous to those obtained in experimental group 2. No antibody response was observed in unimmunized mice. The 95% probability limits of the mean is given in parentheses. ND, not determined. Tg, transgenic.