Table 2.
Description of experimental animals and cardiac functional parameters
| Control | R26loxp-TAp57k/+; Mlc2v-crek/+ | |
| n = 6 | n = 4 | |
| Age (days old) | 136 ± 22 | 133 ± 23 |
| Body Weight (grams) | 32 ± 1 | 34.2 ± 1 |
| Heart Weight (mg) | 162 ± 2 | 214 ± 2 |
| Heart/Body Weight Ratio (mg/g) | 5.03 ± 0.45 | 6.19 ± 0.75 |
| Baseline functional parameters | ||
| LVSP (mmHg) | 97 ± 9 | 107 ± 3 |
| LVEDP (mmHg) | 3.4 ± 1.4 | 2 ± 1 |
| LVDP (mmHg) | 94 ± 10 | 105 ± 3 |
| HR (bpm) | 418 ± 22 | 387 ± 24 |
| RPP (bpm × mmHg) | 37,920 ± 3,064 | 41,218 ± 2,794 |
| dP/dt max (mmHg/sec) | 2,461 ± 262 | 2,764 ± 180 |
| CF (ml/min) | 4.53 ± 0.24 | 4.58 ± 0.26 |
| Functional Parameters post I/R | ||
| LVSP (mmHg) | 75 ± 3.5 | 87 ± 11 |
| LVEDP (mmHg) | 39 ± 4.3 | 23 ± 8 |
| LVDP (mmHg) | 30 ± 6* | 63 ± 15* |
| HR (bpm) | 362 ± 37 | 368 ± 17 |
| RPP (bpm × mmHg) | 10,361 ± 2,077** | 22,787 ± 4,858** |
| dP/dt max (mmHg/sec) | 944 ± 193 | 1,513 ± 332 |
| CF (ml/min) | 2.38 ± 0.24** | 3.5 ± 0.5** |
Values are means ± SE. The two asterisks (**) indicate statistical significance with a probability of p < 0.05 (unpaired t-test), while the one asterisk indicates a probability of p = 0.05. One-way ANOVA followed by Fisher post hoc test also indicated significant difference among these groups. There was also a strong trend for lower LVEDP in the transgenic hearts; however with the small number of tested animals this did not reach statistical significance. LVSP, left ventricular systolic pressure; LVEDP, left ventricular end diastolic pressure; LVDP, left ventricular developed pressure, HR, heart rate; RPP, rate pressure product; CF, coronary flow.