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OT-triggered APs are exclusively governed by IPSPs. A, In the presence of CNQX, OT (50 nm) dramatically increased IPSP activity and firing (middle), an action that was totally blocked by picrotoxin (5 μm; right). B1, In the presence of CNQX and AP5, a positive step current was required to depolarize the cell and trigger firing. B2, OT (50 nm) under the same conditions and in the same neuron triggered IPSPs (arrowhead) and AP firing without depolarizing the membrane.
