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Cytotoxicity of UK-1 Analogs against MCF-7 and A549 cell lines
| Compound | IC50 for CF7 (μM)a | IC50 for A549 (μM)a |
|---|---|---|
| UK-1 | 1.4 ± 0.9 | 2.0 ± 0.5 |
| 1 | 4±2 | 12±3 |
| 2 | >50 | >50 |
| 3 | 7±1 | 35±4 |
| 12 | 15 ± 5 | 40 ± 10 |
| 13 | 10 ± 8 | 11 ± 1 |
| 14 | 30 ± 10 | 14 ± 4 |
| 15 | 31 ± 7 | 39 ±17 |
| 16 | > 50 | 41 ±17 |
| 17 | 13 ± 2 | 11 ± 1 |
| MMCb | 0.20 ± 0.07 | 0.4 ± 0.1 |
determined using the AlamarBlue assay. See Experimental Section for details.
Mitomycin C.
