Table 1.
Spontaneous behavioral parameters for 12 month old Cln3-/- and C57BL/6J mice
| Parameter | C57BL/6J (n=6) | Cln3-/- (n=7) | P |
|---|---|---|---|
| Horizontal beam interruptions | 5028 ± 228 | 4102 ± 149 | 0.005 |
| Total distance moved (cm) | 2934 ± 216 | 2006 ± 189 | 0.008 |
| Number of horizontal movements | 231 ± 6.6 | 201 ± 9.0 | 0.025 |
| Time spent moving (sec) | 290 ± 18 | 218 ± 20 | 0.023 |
| Vertical beam interruptions | 269 ± 17 | 156 ± 19 | 0.001 |
| Number of vertical movements | 116 ± 8.6 | 73 ± 7.3 | 0.003 |
| Time spent vertical (sec) | 91 ± 6.1 | 59 ± 9.7 | 0.021 |
| Stereotypic beam breaks | 2879 ± 179 | 2383 ± 73 | 0.020 |
| Number of stereotypic episodes | 168 ± 1.8 | 156 ± 4.0 | 0.027 |
| Time spent in stereotypic behavior (sec) | 251 ± 15 | 239 ± 15 | 0.563 |
| Number of clockwise revolutions | 10 ± 1.8 | 7.1 ± 1.3 | 0.234 |
| Number of counterclockwise revolutions | 9.7 ± 1.0 | 6.6 ± 1.4 | 0.127 |
| Distance traveled in cage margin (cm) | 1944 ± 217 | 1158 ± 115 | 0.007 |
| Time spent in cage margin (sec) | 652 ± 23 | 575 ± 45 | 0.174 |
| Distance traveled in cage center (cm) | 991 ± 51 | 849 ± 99 | 0.255 |
| Time spent in cage center (sec) | 248 ± 23 | 325 ± 45 | 0.174 |