Table 2.
Hypoxia Microarray Results
| Gene name | Accession no. | Symbol | PFD 7 | PFD 10 | PFD 14 |
|---|---|---|---|---|---|
| Adducin 1 (α) | NM_013457 | Add1 | 0.00 | 0.00 | 188.56 |
| RIKEN cDNA A230056J06 gene | NM_023328 | Agtpbp1 | 0.00 | −105.94 | 0.00 |
| B-cell leukemia/lymphoma 2 | NM_009741 | Bcl2 | 0.00 | −135.56 | 0.00 |
| Basic helix-loop-helix domain containing, class B2 | NM_011498 | Bhlhb2 | 0.00 | 85.90 | −143.05 |
| Catalase | NM_009804 | Cat | −140.24 | 119.40 | 0.00 |
| Down-regulator of transcription 1 | NM_026106 | Dr1 | 0.00 | 104.82 | 0.00 |
| Endothelin converting enzyme 1 | NM_199307 | Ece1 | −111.42 | −30.36 | −24.05 |
| HIF-1α | NM_010431 | Hif1a | −188.92 | 48.65 | 105.36 |
| IGF-II | NM_010514 | Igf2 | 0.00 | 0.00 | 119.20 |
| IL-6 | NM_031168 | Il6 | −198.98 | −101.71 | 159.58 |
| Protein phosphatase 2a, catalytic subunit, beta | NM_017374 | Ppp2cb | −167.21 | 4.83 | 159.59 |
| Proteasome (prosome, macropain) 28 subunit, beta | NM_011190 | Psme2 | 0.00 | −120.18 | 0.00 |
| Ribosomal protein L37a | NM_009084 | Rpl37a | 0.00 | 0.00 | 118.94 |
| Ribosomal protein S2 | NM_008503 | Rps2 | 0.00 | −36.51 | 109.70 |
| U1 small nuclear ribonucleoprotein polypeptide A | NM_009224 | Snrp70 | 0.00 | −121.53 | 107.78 |
| Superoxide dismutase 2, mitochondrial | NM_013671 | Sod2 | 0.00 | −125.43 | 0.00 |
| Spectrin β2 | NM_009260 | Spnb2 | 0.00 | −4.86 | 109.26 |
| Uncoupling protein 2 (mitochondrial, proton carrier) | NM_011671 | Ucp2 | 0.00 | −114.84 | 145.72 |
This table lists the 18 hypoxia inducible genes that were identified as being differentially regulated between the fracture calluses of HIF-1α+/+ and HIF-1α+/− mice. The gene names, accession numbers, symbols, and percent differences as given. Percent difference values of 0.00 indicate no difference, values > 0.00 indicate increased expression in HIF-1α+/+ samples, and values < 0.00 indicate increased expression in HIF-1α+/− samples.