Table 1.
miRNAs differentially expressed between NPMc+ (mutated) vs. NPMc− (unmutated) AML patients
| miRNA | Parametric P value | FDR* | Fold change |
|---|---|---|---|
| Up-regulated in NPMc+ | |||
| hsa-miR-10a | <1e-07 | <1e-07 | 20 |
| hsa-miR-10b | <1e-07 | <1e-07 | 16.67 |
| hsa-miR-100 | <1e-07 | <1e-07 | 4.35 |
| hsa-let-7a-3 | <1e-07 | <1e-07 | 3.45 |
| hsa-miR-21 | 3.16E-05 | 4.24E-04 | 3.33 |
| hsa-let-7f | 2.63E-04 | 1.97E-03 | 3.33 |
| hsa-let-7c | 4.00E-07 | 1.45E-05 | 3.33 |
| hsa-miR-16b | 2.14E-04 | 1.80E-03 | 3.23 |
| hsa-miR-16a | 7.21E-04 | 4.16E-03 | 2.94 |
| hsa-let-7a-2 | 2.00E-07 | 8.50E-06 | 2.94 |
| hsa-miR-19b | 1.29E-04 | 1.31E-03 | 2.94 |
| hsa-miR-18a | 8.60E-06 | 1.97E-04 | 2.86 |
| hsa-miR-29c | 2.59E-04 | 1.97E-03 | 2.78 |
| hsa-miR-29a | 3.97E-04 | 2.59E-03 | 2.78 |
| hsa-let-7a-1 | 1.60E-06 | 4.52E-05 | 2.71 |
| hsa-miR-16-1 | 5.07E-04 | 3.07E-03 | 2.63 |
| hsa-miR-29b | 1.11E-03 | 5.64E-03 | 2.56 |
| hsa-miR-24 | 2.32E-04 | 1.84E-03 | 2.51 |
| hsa-miR-20 | 1.21E-05 | 2.20E-04 | 2.44 |
| hsa-miR-17 | 3.83E-03 | 1.52E-02 | 2.33 |
| hsa-miR-369 | 1.23E-03 | 6.11E-03 | 2.27 |
| hsa-let-7 g | 1.02E-03 | 5.30E-03 | 2.27 |
| hsa-let-7d | 7.60E-06 | 1.93E-04 | 2.13 |
| hsa-miR-19a | 9.30E-06 | 1.97E-04 | 2.13 |
| hsa-miR-106 | 5.52E-05 | 6.48E-04 | 2.13 |
| hsa-miR-16-2 | 3.35E-04 | 2.30E-03 | 2.04 |
| hsa-miR-195 | 1.50E-03 | 7.32E-03 | 2.04 |
| hsa-miR-102 | 8.10E-03 | 2.66E-02 | 2.00 |
| hsa-miR-152 | 3.17E-03 | 1.30E-02 | 1.89 |
| hsa-miR-9 | 2.03E-03 | 9.09E-03 | 1.85 |
| hsa-miR-142 | 2.04E-03 | 9.09E-03 | 1.82 |
| hsa-miR-378 | 3.14E-03 | 1.30E-02 | 1.82 |
| hsa-miR-98 | 1.69E-03 | 8.12E-03 | 1.64 |
| hsa-miR-374 | 3.15E-04 | 2.22E-03 | 1.64 |
| hsa-miR-15a | 1.91E-03 | 8.99E-03 | 1.61 |
| hsa-miR-155 | 6.78E-03 | 2.39E-02 | 1.54 |
| Down-regulated in NPMc+ | |||
| hsa-miR-22 | 1.10E-05 | 2.15E-04 | 0.31 |
| hsa-miR-192 | 2.43E-05 | 3.86E-04 | 0.67 |
| hsa-miR-128a | 2.93E-05 | 4.24E-04 | 0.65 |
| hsa-miR-383 | 9.20E-05 | 1.02E-03 | 0.52 |
| hsa-miR-373 | 2.07E-04 | 1.80E-03 | 0.57 |
| hsa-miR-324 | 2.20E-04 | 1.80E-03 | 0.58 |
| hsa-miR-127 | 2.74E-04 | 1.99E-03 | 0.45 |
| hsa-miR-373* | 4.61E-04 | 2.85E-03 | 0.58 |
| hsa-miR-139 | 5.73E-04 | 3.38E-03 | 0.49 |
| hsa-miR-193b | 9.32E-04 | 5.01E-03 | 0.55 |
| hsa-miR-145 | 9.38E-04 | 5.01E-03 | 0.65 |
| hsa-miR-498 | 2.23E-03 | 9.78E-03 | 0.56 |
| hsa-miR-135a | 2.40E-03 | 1.02E-02 | 0.57 |
| hsa-miR-299 | 2.42E-03 | 1.02E-02 | 0.66 |
| hsa-miR-429 | 3.90E-03 | 1.52E-02 | 0.63 |
| hsa-miR-493 | 3.97E-03 | 1.53E-02 | 0.53 |
| hsa-miR-326 | 4.65E-03 | 1.76E-02 | 0.63 |
| hsa-miR-204 | 4.89E-03 | 1.80E-02 | 0.61 |
| hsa-miR-198 | 8.20E-03 | 2.66E-02 | 0.65 |
| hsa-miR-486 | 8.23E-03 | 2.66E-02 | 0.45 |
MiRNAs are sorted by P value of the univariate test (BRB tools). The first 56 genes are significant at the nominal 0.01 level of the univariate test.
*FDR, False discovery rate or q value is the expected percentage of genes identified by chance.