Fig. 1.

Voxelwise resting-state functional connectivity maps for a seed region (solid black circle) in mPFC (ventral: −3, 39, −2). (A) Qualitatively, the rs-fcMRI map for the mPFC (ventral) seed region reveals the commonly observed adult connectivity pattern of the default network (9, 18, 19). The connectivity map in children, however, significantly deviates from that of the adults. Functional connections with regions in the posterior cingulate and lateral parietal regions (highlighted with blue open circles) are present in the adults but absent in children. (B) These qualitative differences between children and adults are confirmed by the direct comparison (random effects) between adults and children. mPFC (ventral) functional connections with the posterior cingulate and lateral parietal regions are significantly stronger in adults than children.