Skip to main content
. 2008 Feb 28;105(10):3992–3997. doi: 10.1073/pnas.0711700105

Fig. 2.

Fig. 2.

Impaired glucose tolerance and insulin secretion, but normal insulin sensitivity in synaptotagmin-7 mutant mice. (A) An i.p. glucose tolerance test (IPGTT) was performed on overnight-fasted synaptotagmin-7 mutants and wild-type control mice. Blood glucose levels before and at 15, 30, 60, 90, and 120 min after glucose injection (2 mg per gram of body weight) were measured. Synaptotagmin-7 mutant (Syt7−/−) mice (filled square, n = 13) exhibited glucose intolerance as evidenced by higher glucose concentration after injection and delayed clearance of glucose. ∗, P < 0.02, ∗∗, P < 0.005 vs. control (filled circle, n = 17). (B) Plasma insulin levels in control and synaptotagmin-7 mutant mice before and at 8, 15, 30, and 60 min of IPGTT were determined. Synaptotagmin-7 mutant mice showed insulin-secretory deficiency, especially in the first 15 min, upon glucose challenge. n = 10 for control (filled circle) and 11 for mutant (filled square). ∗, P < 0.05, ∗∗, P < 0.005. (C) Blood glucose levels were measured in 2-h-fasted control and mutant mice before and at 15, 30, and 60 min after injection of 1 unit/kg insulin. Synaptotagmin-7 mutant mice appeared to have higher insulin sensitivity than their wild-type control. ∗, P < 0.03, n = 17.