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. 2008 Mar 3;105(10):3933–3938. doi: 10.1073/pnas.0708917105

Fig. 1.

Fig. 1.

MI-219 binds potently and selectively to MDM2 and mimics key p53 residues. (A) Chemical structures of MDM2 inhibitors and control compounds. (B) Competitive binding to recombinant human MDM2 and MDMX proteins. (C) Predicted binding model of MI-219 in complex with MDM2 and superpositioned to the MDM2–p53 crystal structure. MI-219 is shown in ball and stick representation, and the key residues are shown as sticks. Surface representation of MDM2 is shown with carbons in gray, nitrogen in blue, oxygen in red, and sulfur in yellow. For clarity, hydrogen atoms are not included. The figure was generated with the program Pymol.