Fig. 1.

H chain Tg BALB/c mice show drastic differences in their L chain repertoires. The endogenous L chain repertoires in anti-DNA H chain Tg mice have previously been analyzed by constructing LPS hybridomas from splenic B cells (4, 22). Vκ12/13A predominates in hybridomas from VH3H9 mice, with Vκ21D and Vκ38c following at lower percentages (A). Vκ12/13A is absent in VH56R Tg mice (22), whereas Vκ21D predominates and Vκ38c is less prevalent (B). Vκ38c is abundant in VH56R/76R Tg mice (22), whereas Vκ12/13A and Vκ21D are absent (C). Additional Vκ are expressed at low frequencies but are not represented in the figure.