Table 2.

Oligomannose dendrons as inhibitors of 2G12 binding to multivalent glycan displays

Compound	Glycan array assay, normal denisty, IC50, μM		Glycan array assay, high-density			2G12/gp120 ELISA IC50, μM
			IC50, μM		KD,sol, μM
	Per dendron	Per oligomannose	Per dendron	Per oligomannose		Per dendron	Per oligomannose
3	42	42	2,100	2,100	350 ± 98	1,100	1,100
13	0.29	0.87	100	300	17 ± 5.6	160	480
14	0.0046	0.041	1.2	11	0.21 ± 0.088	10*	90*
15	0.0041	0.10	0.022	0.56	0.0039 ± 0.0013	0.24	6.0
4	18	18	1,000	1,000	180 ± 99	530	530
16	0.095	0.29	3.5	11	0.61 ± 0.19	36	107
17	0.0030	0.027	0.020	0.18	0.0034 ± 0.00049	0.54	4.8
18	0.0031	0.078	0.018	0.46	0.0031 ± 0.00041	0.29	7.3

* Extrapolated from the concentration of 40% inhibition.