Table 3. Genotypic and allelic counts, frequencies, and p-values for three LOXL1 polymorphisms in different subtypes of exfoliation syndrome.
|
Phenotype |
LOXL1 SNPs |
rs1048661
(R141L) |
rs3825942
(G153D) |
rs2165241 |
|||
|
GG/GT/TT |
G/T |
GG/GA/AA |
G/A |
CC/CT/TT |
C/T |
||
| XFO
(n=95) |
Counts |
62/32/0 |
156/32 |
79/15/0 |
173/15 |
4/43/46 |
51/135 |
| Frequency |
0.660/0.340/0.0 |
0.830/0.170 |
0.840/0.160/0.0 |
0.920/0.080 |
0.043/0.462/0.495 |
0.274/0.726 |
|
| p-Value |
1.37x10-3 |
5.44x10-4 |
9.18x10-4 |
1.01x10-4 |
5.99x10-11 |
2.30x10−11 |
|
|
| |||||||
| XFG
(n=133) |
Counts |
95/35/2 |
225/39 |
128/4/0 |
260/4 |
9/47/76 |
65/199 |
| Frequency |
0.720/0.265/0.015 |
0.852/0.148 |
0.970/0.030/0.0 |
0.985/0.015 |
0.068/0.356/0.576 |
0.246/0.754 |
|
| p-Value |
1.49x10-5 |
2.53x10-6 |
1.21x10-11 |
5.59x10-13 |
4.83x10−17 |
4.17x10-17 |
|
|
| |||||||
| XFU
(n=59) |
Counts |
40/16/1 |
96/18 |
53/4/0 |
110/4 |
3/29/27 |
35/83 |
| Frequency |
0.702/0.280/0.018 |
0.842/0.158 |
0.930/0.070/0.0 |
0.965/0.035 |
0.051/0.491/0.458 |
0.297/0.703 |
|
| p-Value |
8.39x10-3 |
2.17x10-3 |
1.25x10-4 |
1.67x10-5 |
8.24x10-7 |
3.28x10-7 |
|
|
| |||||||
| XFS
(n=287) |
Counts |
197/83/3 |
477/89 |
260/23/0 |
543/23 |
16/119/149 |
151/417 |
| Frequency |
0.696/0.293/0.011 |
0.843/0.157 |
0.919/0.081/0.0 |
0.959/0.041 |
0.056/0.419/0.525 |
0.266/0.734 |
|
| p-Value |
2.85x10-8 |
7.74x10-9 |
7.44x10-15 |
3.10x10-17 |
1.24x10-22 |
4.85x10-24 |
|
|
| |||||||
| Controls (n=333) | Counts |
162/140/28 |
464/196 |
216/98/18 |
530/134 |
94/174/60 |
362/294 |
| Frequency | 0.491/0.424/0.085 | 0.703/0.297 | 0.651/0.295/0.054 | 0.798/0.202 | 0.287/0.530/0.183 | 0.552/0.448 | |
Genotypic and allelic p-values were tabulated individually between each of the exfoliation subtypes and controls (n=333).