Table 2. Glutathione S-transferase genotypes and the risk of developing glaucoma.
| GST genotypes | Controls (n=120) | Glaucoma patients (n=107) | Odds ratio | 95% Confidence interval | p-Value |
|---|---|---|---|---|---|
| T1M1 |
102 (85%) |
43 (40.2%) |
Reference |
- |
- |
| T0M0 |
3 (2.5%) |
9 (8.4%) |
7.12 |
1.65 – 35.0 |
0.002 |
| T1M0 |
10 (8.3%) |
38 (35.5%) |
9.01 |
3.89 – 21.3 |
0.00001 |
| T0M1 | 5 (4.2%) | 17 (15.9%) | 8.07 | 2.58 – 26.9 | 0.00001 |
The frequency of all deletion genotypes investigated was significantly greater among glaucoma patients than controls (after Bonferroni correction, p-value < 0.0167 was considered statistically significant).