Table 3. Glutathione S-transferase genotypes and the risk of developing primary open-angle glaucoma.
| GST genotypes | Controls (n=120) | POAG patients (n=49) | Odds ratio | 95% Confidence interval | p-Value |
|---|---|---|---|---|---|
| T1M1 |
102 (85%) |
18(36.7%) |
Reference |
- |
- |
| T0M0 |
3 (2.5%) |
3 (6.2%) |
5.67 |
0.83 – 39.2 |
0.06 |
| T1M0 |
10 (8.3%) |
18 (36.7%) |
10.2 |
3.72 – 28.6 |
0.00001 |
| T0M1 | 5 (4.2%) | 10 (20.4%) | 11.3 | 3.07 – 44.0 | 0.00001 |
The frequency of the T1M0 and T0M1 genotypes was significantly greater in POAG patients than controls (p=0.00001), while the frequency of the T0M0 null genotype which was not significant (p=0.06). After Bonferroni correction, p-value < 0.0167 was considered statistically significant.