Table 4. Glutathione S-transferase genotypes and the risk of developing pseudoexfoliation glaucoma.
| GST genotypes | Controls (n=120) | PEG patients (n=29) | Odds ratio | 95% Confidence interval | p-Value |
|---|---|---|---|---|---|
| T1M1 |
102 (85%) |
11 (37.9%) |
reference |
- |
- |
| T0M0 |
3 (2.5%) |
3 (10.3%) |
9.27 |
1.28 – 68.5 |
0.021 |
| T1M0 |
10 (8.3%) |
10 (34.5%) |
9.27 |
2.81 – 31.3 |
0.00001 |
| T0M1 | 5 (4.2%) | 5 (17.3%) | 9.27 | 1.93 – 45.8 | 0.003 |
All deletion GST genotype frequencies were greater in PEG patients than controls, except for the T0M0 null genotype, which fell slightly short of significance (p=0.021). After Bonferroni correction, p-value < 0.0167 was considered statistically significant.