Table 5. Glutathione S-transferase genotypes and the risk of developing primary angle-closure.
| GST genotypes | Controls (n=120) | PACG patients (n=29) | Odds ratio | 95% Confidence interval | p-Value |
|---|---|---|---|---|---|
| T1M1 |
102 (85%) |
14 (48.3%) |
Reference |
- |
- |
| T0M0 |
3 (2.5%) |
3 (10.3%) |
7.29 |
1.04 – 51.9 |
0.034 |
| T1M0 |
10 (8.3%) |
10 (34.5%) |
7.29 |
2.30 – 23.5 |
0.0002 |
| T0M1 | 5 (4.2%) | 2 (6.9%) | 2.91 | 0.35 – 19.7 | 0.225 |
The frequency of the T1M0 genotype was significantly greater in PACG patients than in controls (p=0.0002), whereas the prevalence of T0M0 and T0M1 genotypes were not statistically different from controls. After Bonferroni correction, p-value < 0.0167 was considered statistically significant.